Dosing Guidelines

This page contains general information on common DIY HRT dosing. Always adjust with medical guidance when possible.

Estradiol (Non-Injection)

Form	Recommended Dose Range	Frequency	Notes
Oral Estradiol (17-β)	2–8 mg	Daily	Lower doses reduce liver strain; higher doses may increase T suppression but carry more risk.
Transdermal Patch	50–200 µg (0.05–0.2 mg)	Replace according to package instructions (usually every 3–4 days)	Provides steadier blood levels; safer for liver than oral.
Estradiol Gel	1–5 mg applied topically	Daily	Absorption varies by product and application site, typically 0.75mg/pump

Estradiol Injections

Injectable estradiol comes in several ester forms. Dosage depends on the ester type and vial concentration. A common calculation is: Desired Dose ÷ Vial Strength = Injection Volume. Example: a 5 mg dose drawn from a 40 mg/mL vial → 5 ÷ 40 = 0.125 mL (≈0.13 mL).

Formulation	Recommended Dose	Injection Volume*	Frequency
Estradiol Valerate (EV)	4 mg	0.1 mL (40 mg/mL)	Every 5 days
Estradiol Cypionate (EC)	5 mg	≈0.13 mL (40 mg/mL)	Every 7 days
Estradiol Enanthate (EEn)	6 mg	0.15 mL (40 mg/mL)	Every 7 days
Estradiol Enanthate (EEn)	8 mg	0.2 mL (40 mg/mL)	Every 10 days
Estradiol Undecylate (EUn) (MCT Oil)	32 mg	0.3 mL (80 mg/mL)	Every 31 days

*Injection volume assumes typical vial concentrations (40 mg/mL or 80 mg/mL). Always confirm your vial strength before calculating your own dose.

Testosterone Blockers

Drug	Recommended Dose	Frequency	Notes
Cyproterone Acetate (oral)	12.5 mg	Every 2 days
Spironolactone (oral)	50–200 mg	Every day	Doses over 100mg are commonly taken in 100mg twice daily.
Bicalutamide (oral)	50 mg	Every day

Testosterone Blocker Side-Effects

Cyproterone Acetate

Spironolactone

Bicalutamide

5-Alpha Reductase inhibitors

Form	Recommended Dose Range	Frequency	Notes
Finasteride	1-5mg	Daily	---
Dutasteride	---	---	---

Progesterone

Form	Recommended Dose	Frequency	Notes
Examples to be added